Sivakumar Gowder
InTeOp
2013
ISBN: 9535109464 9789535109464
252 pages
PDF
This book covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development.
This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life.
Contents
Preface
Section 1 Toxicity
1 Pre-Clinical Assessment of the Potential Intrinsic Hepatotoxicity of Candidate Drugs
2 The Kidney Vero-E6 Cell Line: A Suitable Model to Study the Toxicity of Microcystins
3 Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?
4 Screening of Herbal Medicines for Potential Toxicities
5 New Trends in Genotoxicity Testing of Herbal Medicinal Plants
Section 2 Drug Testing and Development
6 Animal Models in Drug Development
7 Renal Transporters and Biomarkers in Safety Assessment
8 Autophagy: A Possible Defense Mechanism in Parkinson's Disease?
9 Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human
10 Plasma Methadone Level Monitoring in Methadone Maintenance Therapy: A Personalised Methadone Therapy
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