A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body
The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition:
Provides a comprehensive overview of drug transporters
Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy
Describes transporter-mediated drug disposition, a newly emerging field in drug therapy
Gives a comprehensive summary of drug transport across biological membranes
in the liver, brain, kidney, and intestine
Provides balanced coverage of mechanistic aspects and functional outcomes
Features chapters contributed by distinguished scientists in their specialty areas
Provides sufficient detail to enable non-specialists to understand the principles and techniques
This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.

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