This book explores how the use of site-specific protein modification relates to a wide variety of biotechnology processes and products, such as protein microarrays, hydrogels, controlled-release pharmaceuticals, and biotherapeutics, and proteomics.

This is an encyclopedic work describing the many approaches to the site-specific modification of proteins. More than 2,000 references are cited describing the development of the various reagents.
With chapters focusing on analyses of individual amino acids, additional chapters cover chemical cross-linking and the chemical cleavage of peptide chains.
There is considerable reference to the use of site-specific chemical modification in proteomics.

Table of Contents
Preface
Chapter 1 The Site-Specific Chemical Modification of Proteins
Chapter 2 The Modification of Amino Groups
Chapter 3 The Modification of Histidine Residues
Chapter 4 The Modification of Arginine
Chapter 5 The Modification of Carboxyl Groups
Chapter 6 The Modification of Cysteine
Chapter 7 The Modification of Cystine
Appendix I: Microprocedure for the Reduction and Carboxymethylation of Proteins
Chapter 8 The Modification of Methionine
Chapter 9 The Modification of Tyrosine
Chapter 10 The Chemical Modification of Tryptophan
Chapter 11 The Chemical Cleavage of Peptide Bonds
Chapter 12 The Chemical Cross-Linking of Peptide Chains
Appendix I: Some Reagents Used in the Modification of Proteins
Appendix II: Assay of Protein Concentration in Solution

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