This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field.

An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors).
Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis.
The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activationand plasmin action addresses a novel aspect of fibrinolysis.

Contents
Preface
1 An Insight into the Abnormal Fibrin Clots — Its Pathophysiological Roles
2 Fibrinolysis at the Interface of Thrombosis and Inflammation — The Role of Neutrophil Extracellular Traps
3 S100A10: A Key Regulator of Fibrinolysis
4 Comparative Fibrinolysis
5 Thrombolytic/Fibrinolytic Mechanism of Natural Products
6 Clinical Application of Fibrinolytic Assays
7 Coagulation and Fibrinolysis Markers and Their Use for the Prediction of High Risk Patients with Venous Thromboembolism Following Total Hip Arthroplasty
8 Thrombolysis or Operation: That is the Question in Prosthetic Valve Thrombosis
9 Coagulation and Fibrinolysis Abnormalities in Patients with Muscular Dystrophy

Download File Size:9.81 MB

---