This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.

Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis.
Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS.
• A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis
• Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options
• Each chapter is translational and focuses on current research and impact on diagnosis and treatment options.

Contents
Foreword
Preface
Contributors
SECTION 1 Pathogenesis
1.Immune regulation of multiple sclerosis
2.Pathology of multiple sclerosis and related inflammatory demyelinating diseases
3.The good and the bad of neuroinflammation in multiple sclerosis
4.Demyclination in multiple sclerosis
5.Axonal loss in multiple sclerosis: causes and mechanisms
6.Insights from magnetic resonance imaging
7.Infections and multiple sclerosis
8.The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment
SECTION 2 Epidemiology and genetics
9.Multiple sclerosis genetics
10.Genetics of primary progressive multiple sclerosis
11.The epidemiology of multiple sclerosit: insights to disease pathogenesis
SECTION 3 Diagnosis and disease course
12. Multiple sclerosis: diagnosis, differential diagnosis, and clinical presentation
13. MRI mimies of multiple sclerosis
14. Diagnosis of multiple sclerosis
15. The clinical course of multiple sclerosis
16. Early prognosis of multiple sclerosis
17. Clinical outcome measures in multiple sclerosis
18. MKI outcomes in the diagnosis and disease course of multiple sclerosis
19. Multiple sclerosis in children
SECTION 4 Treatment
20. Clinical trials in multiple sclerosis
21. Glucocorticoid treatment of multiple sclerosis
22. Disease-modifying agents in multiple sclerosis
23. Immunosuppressive treatments in multiple sclerosis
24. Symptomatic treatment and management of multiple sclerosis
25. Future treatment approaches to multiple sclerosis
SECTION 5 Other demyelinating diseases
26. Neuromyelitis optica (Devic's syndrome)
27. Acute disseminated encephalomyelitis and other inflammatory demyelinating variants
28. Acute inflammatory myelopathies
SECTION 6 Capita selecta
29. Clinical neurophysiology of multiple sclerosis
30. Cerebrospinal fluid analysis
Index

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