This volume is dedicated to Chronic Obstructive Pulmonary Disease (COPD) - an increasingly recognized cause of morbidity and mortality. This volume brings together an international group of experts in COPD to provide in depth reviews of clinical perspectives into COPD.

Over the next 10 years, deaths due to COPD are expected to increase by 30% and, by 2030, COPD is estimated to be the third leading cause of death worldwide.
Research into the pathophysiology and management of COPD over the past decade has progressed immensely with greater understanding of the global burden of COPD, its pathophysiology, better understanding of the multisystemic manifestations of COPD, and, most importantly, novel and more effective therapeutic strategies.

Topics range from the diagnosis of airflow limitation by spirometry; distinguishing COPD from another common obstructive lung disease, asthma; alpha-1-antitrypsin deficiency and opportunities to diagnose this most common hereditary cause of COPD and as a paradigm for the development of novel therapeutics; the overlap syndrome - the concurrence of two epidemic disorders: COPD and obstructive sleep apnea; and pulmonary rehabilitation, one of the most effective treatments for COPD.

Contents
Preface
1 Airflow Limitation and Spirometry
2 Asthma and COPD - Overlapping Disorders or Distinct Processes?
3 Alpha-1 Antitrypsin Deficiency — A Missed Opportunity in COPD?
4 Antiproteases as Therapeutics to Target Inflammation in Chronic Obstructive Pulmonary Disease
5 Sleep and Chronic Obstructive Pulmonary Disease - the Role of Oxidative Stress in Overlap Syndrome
6 Chronic Obstructive Pulmonary Disease and Sleep Quality
7 Advances in Comprehensive Pulmonary Rehabilitation for COPD Patients

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