The objectives of this book: to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms; to highligh the molecular dysregulation of niche biology leading to the disease; to review the therapeutical targets described within stem cell niches.

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime.
Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell.

Contents
Preface
1 Delineation of Niches which Support Hematopoiesis
2 The Adult Hematopoietic Niches — Cellular Composition, Histological Organization and Physiological Regulation
3 CXCR4 in Central and Peripheral Lymphoid Niches – Physiology, Pathology and Therapeutic Perspectives in Immune Deficiencies and Malignancies
4 Hematopoietic Stem Cells, Tumor Cells and Lymphocytes — Party in the Bone Marrow
5 Male stem Cell Niche and Spermatogenesis in the Drosophila testis — A Tale of Germline-Soma Communication
6 Adult Stem Cell Niches — Stem Cells in the Female Reproductive System
7 Adult Hepatic Progenitor Cells
8 Typical and Atypical Stem Cell Niches of the Adult Nervous System in Health and Inflammatory Brain and Spinal Cord Diseases
9 The Role of the “Cancer Stem Cell Niche” in Cancer Initiation and Progression

Download File Size:14.5 MB

---