Adam and Alice are reaching the age when some of the children created by the fertility treatment that spawned them begin to turn feral. Will they succomb to the same physiological horror that destroyed their parents? Every change brings on terror the voice cracking as it changes, the swelling of the breasts, the coarsening of down into actual hair. Their aunt, Cynthia, oversees renovations to the Twisden family's Manhattan residence torn apart by the children's parents at their most savage and struggles to give her niece and nephew the unconditional love they never had. Meanwhile, in the world outside, the forces of good and evil collide as a troop of feral offspring threatens to invade the refuge Cynthia is so determined to construct behind the Twisdens' walls.

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