This authoritative summary of the basics of small system, or nonmacroscopic, thermodynamics was written by the field's originator. In addition to introducing fundamentals, the book explores environmental variables, examines binding on macromolecules and aggregation, and includes brief summaries of electric and magnetic fields, spherical drops and bubbles, and polydisperse systems. Reprint of the W. A. Benjamin, Inc., New York, 1963 and 1964 editions.