Schrodinger is a suite of molecular modeling packages that take advantage
of the latest technological advances in computational chemistry. Jaguar,
the high-performance ab-initio quantum mechanics application, and
MacroModel, the most trusted name in molecular modeling, have been widely
applied to address the full range of chemical research from materials to
life sciences. Strike is a chemically aware statistical package for
examining structure-property relationships. QSite is a powerful QM/MM
application for studying reaction mechanisms in a variety of systems,
such as protein active sites.

Also, Schrodinger provides a complete suite of software that addresses
the challenges in pharmaceutical research. For structure-based drug
design, Prime is an accurate protein structure prediction package;
Glide performs accurate, rapid ligand-receptor docking; and Liaison
predicts binding affinity. Schrodinger also provides Phase for ligand-based
pharmacophore modeling, and QikProp for ADME properties prediction of drug
candidates. In addition, LigPrep is a rapid 2D to 3D conversion program
that can prepare ligand libraries for further computational analyses.
And most recently, Schrodinger introduced CombiGlide for focused library
design, and Epik for accurate enumeration of ligand protonation states in
biological conditions. Finally, Maestro is the graphical user interface
for all of Schrodinger's computational programs and provides a powerful,
fully-integrated molecular visualization and analysis environment.


The following operating systems are officially supported:
Windows Vista SP1, 32-bit or 64-bit
Windows XP (Home or Pro version) SP2 or SP3, 32-bit only
Windows 2000 SP4, 32-bit only, with Update Rollup 1

However, if you're running Windows 7 32/64bit the setup.exe
will refuse to install. A workaround is to set it to "Windows Vista" Compatibility Mode.
But the application has problems with licensing and crashing especially in Win7x64
possibly due to C++ x86/x64 dll incompatiblities. The best bet for now is to run
it in a 32bit environment. So for now, Windows 7 isn't well supported.

In addition, the following software is required:
Visual C++ 2005 libraries
If these libraries are not already installed or installed during the setup,
you can install them from the /thirdparty folder, or obtain them from:

http://www.microsoft.com/downloads/details.aspx?familyid=200B2FD9-AE1A-4A14-984D-389C36F85647&displaylang=en

Download File Size:948.03 MB

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