Cell Lineage Choice During Haematopoiesis: A Commemorative Issue in Honor of Professor Antonius Rolink by Geoffrey Brown
English | PDF | 2018 | 168 Pages | ISBN : N/A | 16.83 MB
This volume of the International Journal of Molecular Sciences contains a collection of articles by colleagues of Antonius (Ton) Gerardus Rolink (19 April 1953–6 August 2017). Ton had participated in an FP7 Marie Curie Initial Training Network called DECIDE (decision-making within cells and differentiation entity therapies), and the DECIDE partners have submitted articles for this Special Issue. Articles have also been submitted by scientists outside the DECIDE network. We would like to thank all authors for their valuable contributions to this volume.
The DECIDE (decision-making within cells and differentiation entity therapies) network initially arose from the shared interests of Drs Ceredig, Brown, and Rolink in the subject of the process of blood cell formation, or haematopoiesis, and in particular, how progenitor cells differentiate to give rise to the different blood cell types. Haematopoiesis is an archetype cell-lineage system with which to study cell-lineage choice. Research in this area is driven by the need to understand this process at the basic scientific level, as well as abnormal haematopoiesis, in particular, the development of leukaemia. Based largely upon the sequential appearance of blood cells during ontogeny and the close and pairwise relationships between the blood cell types, Brown had initially proposed a radically different (developmental) view of haematopoiesis [ 1 ]. In addition, work with cell lines had demonstrated that the B-cell and myeloid lineages were more closely related than what was envisaged by the “classical” model of haematopoiesis. In this model, after an early bifurcation, lymphocytes derive from a common lymphocyte progenitor (CLP), whereas myeloid cells derive from a common myeloid progenitor (CMP). Clearly, cloned cell lines with both lymphoid and myeloid potential posed a problem for the classical model. Subsequently, the work by Amanda Fisher from Ceredig’s laboratory [ 2 ] showed that cloned lymphoid tumours arising in an interleukin-7 (IL-7) transgenic mouse line possessed both lymphoid and myeloid potentials. Finally, the seminal papers from Ton’s laboratory describing cell lines deficient in the transcription factor Pax-5 and with a multi-lineage (including lymphoid, in this case T-cell and myeloid) potential also contributed to the need to rethink models of haematopoiesis [3,4]. Thus, after some initial discussions, we three (Ceredig, Rolink, and Brown) decided to put some ideas into writing, and in 2009, we published an opinion article in Nature Reviews Immunology [ 5 ]. Based on ideas expressed in this article, we then decided to apply for funding in order to address these ideas. After several iterations and the inclusion of chemists and pharmacists interested in using vitamin D analogues for the control of myeloid cell differentiation and the treatment of leukaemia, funding for the Marie Curie DECIDE network was finally approved in 2013.Visit My Blog For Daily Very Exclusive Content,We Are Here For You And Without You And Your Support We Can’t Continue
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