Features that characterize the aging process include the gradual accumulation of
cell damage after prolonged exposure to oxidative and inflammatory events over a
lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-
oxidant and aberrant immune responses are elevated with age. These adverse events
are often further enhanced by the chronic and slow progressing diseases that
characterize the senescent brain and cardiovascular system. The incidence of some
disorders such as Alzheimer's disease and vascular diseases are sufficiently
prevalent in the extreme elderly that these disorders can arguably be considered
"normal". Aging and Aging-Related Disorders examines the interface between normal
and pathological aging, and illustrates how this border can sometimes be diffuse.
It explores and illustrates the processes underlying the means by which aging
becomes increasingly associated with inappropriate levels of free radical activity
and how this can serve as a platform for the progression of age-related diseases.
The book provides chapters that examine the interactive relationship between
systems in the body that can enhance or sometimes even limit cellular longevity.
In addition, specific redox mechanisms in cells are discussed.

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