The correct functioning of the mammalian brain depends on the integrated activity of myriad
neuronal and non-neuronal cells. Discrete areas serve discrete functions, and dispersed or
distributed communities of cells serve others. Throughout, these networks of activity are
under the control of neuromodulatory systems. One goal of current neuroscientific research
is to elucidate the precise methods by which these systems operate, especially during normal
conscious behaviours and processes. Mircea Steriade and Denis Pare describe the neuronal
properties and networks that exist within and between the cortex and two important sub-
cortical structures: the thalamus and amygdala. The authors explore the changes in these
properties, covering topics including morphology, electrophysiology, architecture and gating;
and comparing regions and systems in both normal and diseased states. Aimed at graduates and
postdoctoral researchers in neuroscience.

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