Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research
(Applied Bioinformatics and Biostatistics in Cancer Research) Srinivasan YMolecular
biology has rapidly advanced since the discovery of the basic flow of information
in life, from DNA to RNA to proteins. While there are several important and
interesting exceptions to this general flow of information, the importance of these
biological macromolecules in dictating the phenotypic nature of living creatures in
health and disease is paramount. In the last one and a half decades, and particularly
after the completion of the Human Genome Project, there has been an explosion of
technologies that allow the broad characterization of these macromolecules in
physiology, and the perturbations to these macromolecules that occur in diseases such
as cancer. In this volume, we will explore the modern approaches used to characterize
these macromolecules in an unbiased, systematic way. Such technologies are rapidly
advancing our knowledge of the coordinated and complicated changes that occur during
carcinogenesis, and are providing vital information that, when correctly interpreted
by biostatistical/bioinformatics analyses, can be exploited for the prevention,
diagnosis, and treatment of human cancers.

The purpose of this volume is to provide an overview of modern molecular biological
approaches to unbiased discovery in cancer research. Advances in molecular biology
allowing unbiased analysis of changes in cancer initiation and progression will be
overviewed. These include the strategies employed in modern genomics, gene expression
analysis, and proteomics.egnasubramanian (Editor), William B. Isaacs (Editor)

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