ICM enpowers a biologist or chemist with a lighting fast access and high
quality interactive 3D views to the entire sturctural database. In just
a few seconds you can browse hundreds of structures of interest load
them, analyze and visualize sequences, structures, alignments, sites,
study pockets and bound ligands and drugs, study surfaces, mutations,
pockets, sequence conservations.
A special compact form of PDB (xpdb-mini) is designed and is freely
distributed to reach the high speed of access. ICM supports multiple
input formats. You can search structural database by field, sequence
pattern and get an interactive table for instant viewing.
ICM offers a rich graphical environment and powerful views for
professional quality of images and molecular animation videos. ICM
supports two kinds of stereo, including a high quality "in-window" mode,
as well as a stereo mode which does not require any special hardware.
A built-in molecular editor allows to draw a compound and immediately
convert it into a live 3D object.
The ICM ('Internal Coordinate Mechanics') software project was
originally desinged around a new molecular mechanics approach and
optimization algorithm for for peptide prediction, homology modeling,
loop simulations, flexible macromolecular docking and refinement, and
then was extended to graphics, molecular animations, chemistry, sequence
analysis, database searches, mathematics, statistics and plotting.
ICM-Pro contains an all atom internal coordinate force field and
efficient algorithm to perform local and global energy optimization of
small or large molecules with respect to an arbitrary subset of
variables. In addition, ICM contains MMFF94 force field for energy
optimization in Cartesian space for any organic molecule. ICM-Pro
allows users to read, build, convert, refine, analyze and superimpose
molecules. Includes graphics tools for diverse molecular rendering,
perspective viewing, depth cueing, etc. Uses both hardware and
side-by-side stereo. Allows saving and printing a screen image as a
compact vectorized postscript file in addition to a compressed bitmap.
Predicting low energy conformations for chemical compounds, peptides,
nucleic acids etc.: Take a peptide sequence and predict its
three-dimensional structure. Of course, the success is not guaranteed,
especially if the peptide is longer than about 25 residues but some
preliminary tests are encouraging. Evaluate local secondary structure
preferences directly from the simulation. Watch a movie with your
peptide folding.
http://www.molsoft.com/icm_pro.html
Download File Size:62.59 MB
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