This book explores how the technologies discussed might be strategically combined or deployed to optimize their contributions to an effective environmental detection capability.

This issue is the summary of a workshop hosted jointly by the Institute of Medicine and the National Research Council in June 2013 to explore alternative cost-effective systems that would meet the requirements for a BioWatch Generation 3.0 autonomous detection system, or autonomous detector, for aerosolized agents.
The workshop discussions and presentations focused on examination of the use of four classes of technologies--nucleic acid signatures, protein signatures, genomic sequencing, and mass spectrometry--that could reach Technology Readiness Level (TRL) 6-plus in which the technology has been validated and is ready to be tested in a relevant environment over three different tiers of temporal timeframes

Contents
Acronyms and Abbreviations
1 Introduction
2 Overview of the BioWatch Program
3 Public Health's Perspective on the Role of BioWatch in the Decision-Making Process
4 Potential Technologies for the BioWatch Program
5 Final Thoughts
APPENDIXES
A References
B Biographical Sketches of Workshop Participants
C Workshop Agenda
D Registered Attendees
E Technology Readiness Levels (TRLs) in the Department of Defense
F White Paper 1: The BioWatch Program: What Information Is Needed to Inform Decision Making?
G White Paper 2: Nucleic-Acid Signatures at Three Levels of Readiness for BioWatch
H White Paper 3: State of the Art for Autonomous Detection Systems Using Immunoassays and Protein Signatures
I White Paper 4: State of the Art for Autonomous Detection Systems Using Genomic Sequencing
J White Paper 5: State of the Art for Autonomous Detection Systems Using Mass Spectrometry

Download File Size:8.13 MB

---