The extraordinary potential of fluorine-containing molecules in medicinal
chemistry and chemical biology has been recognized by researchers outside
of the traditional fluorine chemistry field, and thus a new wave of
fluorine chemistry is rapidly expanding its biomedical frontiers. With
several of the best selling drugs in the world crucially containing fluorine
atoms, the incorporation of fluorine to drug leads has become an essential
practice in biomedical research, especially for drug design and discovery
as well as development.

Focusing on the unique and significant roles that fluorine plays in
medicinal chemistry and chemical biology, this book reviews recent advances
and future prospects in this rapidly developing field. Topics covered include:


Discovery and development of fluorine containing drugs and drug candidates.
New and efficient synthetic methods for medicinal chemistry and the
optimisation of fluorine-containing drug candidates.
Structural and chemical biology of fluorinated amino acids and peptides.
Fluorine labels as probes in metabolic study, protein engineering and
clinical diagnosis.
Applications of 19F NMR spectroscopy in biomedical research.

An appendix presents an invaluable index of all fluorine-containing drugs
that have been approved by the US Food and Drug Administration, including
information on structure and pharmaceutical action.

Fluorine in Medicinal Chemistry and Chemical Biology will serve as an
excellent reference source for graduate students as well as academic and
industrial researchers who want to take advantage of fluorine in biomedical
research.

http://www.amazon.com/Fluorine-Medicinal-Chemistry-Chemical-Biology/dp/1405167203

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