Clinical Nutrition In Health And Disease
Editors: Janos Zempelini, Robert B. Rucker, Donald B. McCormick, John W. Suttie
Recent advances in molecular and cellular biology, analytical chemistry, and
nanotechnology have dramatically improved the understanding of vitamin biomechanics
and the requirements for human function. Vitamin dependant signaling cascades,
alterations in gene expression due to variations in vitamin supply, and DNA stability
and packaging are just a few of the new roles for vitamins that these sciences reveal.
Maintaining its status as the highest quality reference in the field, the Handbook of
Vitamins brings together leading experts in molecular biology, biochemistry, and
physiology to incorporate these new discoveries into this updated and revised fourth
edition.
True to the clinical focus of the previous editions, this book is comprised of
comprehensive summaries that analyze the chemical, physiological, and nutritional
relationships and highlight the newly described and identified functions for all
recognized vitamins. Each chapter covers the physiology, biochemistry, genomics,
and molecular biology of its respective vitamin with specific information on
coenzyme function, cell signaling, vitamin status, and antioxidant and anti-
inflammatory defense. New chapters discuss the recent use of DNA microarrays in
the identification of thousands of vitamin-dependant genes and the modifications
that can be important to epigenetic events and genomic stability. Coverage of
advances in vitamin analysis and assessment discuss new applications of accelerated
mass spectrometry (AMS) that can study vitamin metabolism and turnover at
physiological concentrations. The book also includes an updated dietary reference
intake for vitamins with examples of vitamin-related polymorphisms and genetic
factors that influence the relative need for given vitamins.
Encompassing and incorporating newly identified roles of vitamins in cellular
and organism regulation, the Handbook of Vitamins, Fourth Edition continues to
offer the most respected, up-to-date research with ready clinical application that
we have come to expect.
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